Table 1.
Cortical and trabecular structural indices of mouse femurs (measurements are reported as medians and interquartile ranges)
| 2mWT | 8mWT | HGPS-Ctrl | P1L | P2PZ | P3LPZ | |
| n (%) | 20 (45.5) | 5 (11.4) | 5 (11.4) | 4 (9.1) | 5 (11.4) | 5 (11.4) |
| Cortical structure | ||||||
| BA/TA (%) | 0.990 (0.987–0.990) | 0.996 (0.995–0.996) | 0.996 (0.995–0.996) | 0.996 (0.996–0.996) | 0.997 (0.997–0.997) | 0.997 (0.997–0.997) |
| P value | 0.008 | 0.458 | 0.250 | 0.099 | 0.196 | |
| Ct.Th | 0.12 (0.11–0.12) | 0.19 (0.16–0.19) | 0.16 (0.14–0.16) | 0.12 (0.12–0.13) | 0.23 (0.22–0.24) | 0.19 (0.19–0.24) |
| P value | 0.002 | 0.197 | 0.135 | 0.044 | 0.083 | |
| AppDens (mg/cm3) | 969.35 (960.93–978.90) | 1153.68 (1118.63–1165.93) | 1134.85 (1100.98–1135.35) | 984.22 (972.41–1028.95) | 1165.03 (1089.62–1184.49) | 1147.19 (1139.08–1191.70) |
| P value | <0.001 | 0.284 | 0.156 | 0.276 | 0.186 | |
| MinDens (mg/cm3) | 996.02 (988.05–1006.61) | 1185.57 (1149.99–1197.19) | 1166.29 (1134.72–1167.82) | 1004.22 (992.01–1053.18) | 1190.98 (1110.44–1210.26) | 1177.19 (1166.29–1216.83) |
| P value | <0.001 | 0.331 | 0.106 | 0.322 | 0.249 | |
| Trabecular structure | ||||||
| BV/TV (%) | 0.12 (0.11–0.13) | 0.05 (0.04–0.05) | 0.03 (0.02–0.06) | 0.01 (0.01–0.02) | 0.16 (0.13–0.16) | 0.16 (0.15–0.21) |
| P value | 0.005 | 0.439 | 0.329 | 0.004 | <0.001 | |
| BS/BV (1/mm)* | 72.89 ± 6.07 | 51.64 ± 4.17 | 66.22 ± 4.91 | 60.57 ± 10.13 | 53.23 ± 9.63 | 52.79 ± 18.76 |
| P value | <0.001 | 0.482 | 1.000 | 0.819 | 0.709 | |
| Tb.N (1/mm) | 5.09 (4.40–5.39) | 2.07 (2.00–2.53) | 2.32 (2.10–3.10) | 1.55 (1.15–1.83) | 3.90 (3.34–4.92) | 4.83 (4.63–5.49) |
| P value | <0.001 | 0.406 | 0.293 | 0.094 | 0.014 | |
| Tb.Th (58) | 0.04 (0.04–0.04) | 0.06 (0.06–0.06) | 0.04 (0.04–0.05) | 0.06 (0.06–0.06) | 0.05 (0.04–0.06) | 0.04 (0.04–0.08) |
| P value | <0.001 | 0.294 | 0.317 | 0.458 | 0.430 | |
| Tb.Sp (58) | 0.20 (0.18–0.23) | 0.49 (0.40–0.50) | 0.43 (0.34–0.48) | 0.56 (0.52–0.61) | 0.25 (0.20–0.30) | 0.20 (0.17–0.24) |
| P value | <0.001 | 0.374 | 0.325 | 0.086 | 0.017 | |
| SMI | 2.02 (1.82–2.16) | 2.61 (2.45–2.66) | 3.24 (2.78–3.74) | 3.76 (3.02–4.60) | 1.87 (1.59–2.07) | 1.74 (1.21–1.74) |
| P value | 0.004 | 0.404 | 0.486 | 0.004 | <0.001 | |
| ConnD (1/mm3) | 299.71 (267.09–319.94) | 21.77 (14.75–24.27) | 8.63 (4.75–53.45) | 1.04 (0.45–2.15) | 80.75 (77.07–292.86) | 165.56 (107.70–301.06) |
| P value | <0.001 | 0.494 | 0.305 | 0.106 | 0.051 | |
| AppDens (mg/cm3) | 116.95 (97.94–124.04) | 54.47 (35.55–61.14) | 35.71 (19.23–67.47) | 62.83 (51.17–69.59) | 112.22 (108.16–147.17) | 154.74 (86.27–155.19) |
| P value | 0.002 | 0.442 | 0.446 | 0.034 | 0.009 | |
| MinDens (mg/cm3) | 729.71 (725.32–734.40) | 849.89 (824.75–852.86) | 797.01 (794.75–851.65) | 878.99 (845.97–879.89) | 869.35 (851.42–881.33) | 829.17 (826.92–934.58) |
| P value | 0.001 | 0.425 | 0.341 | 0.237 | 0.281 | |
| DA | 1.921 (1.900–1.956) | 1.143 (1.115–1.201) | 1.280 (1.195–1.288) | 1.336 (1.232–1.391) | 1.278 (1.213–1.312) | 1.472 (1.152–1.625) |
| P value | <0.001 | 0.242 | 0.380 | 0.461 | 0.407 | |
P values represent statistical significance of differences among groups; multiple comparisons are included in the text. AppDens apparent density; BA/TA; bone area fraction; BS/BV, bone surface density; BV/TV, bone volume fraction; ConnDens, connectivity density; Ct.Th, cortical thickness; DA, degree of anisotropy; MinDens, mineral density; SMI, structural model index; Tb.N trabecular number; Tb.Sp, trabecular spacing; Tb.Th, trabecular thickness. Bold values demonstrate significance.
*
These measurements are reported as mean and SD