Table 1.

The reaction processes responsible for generating the protein aggregation data shown in Fig. 2, identified by diverse methods in the original papers (8, 31–33, 39)

The relevant reaction conditions are listed in SI Appendix, Table S4. Types A and B tau oligomers are on- and off-pathway, respectively. αS aggregation data are collected both in the presence and in the absence of camelid nanobodies (Nb). The identities of these reaction processes can depend very sensitively on the reaction conditions. For instance, a drop in pH can induce secondary nucleation in αS (42). Moreover, removing the nucleation inducer used in the tau aggregation experiments causes fibril fragmentation to become a comparatively significant source of new fibrils (43).