Figure 8.

Increased capillary density after Vhl^−/− in the Pde6g^creERT2/+;Vhl^−/− mouse model. 3D remodeling of the vessels with immunofluorescence staining in the retinal flat mount in a Pde6g^creERT2/+;Vhl^flox/flox (A) and Pde6g^creERT2/+;Vhl^−/− (B) mouse at week 6. (C) Bar graphs quantifying the depth of retinal capillary network measured in the retinal flat mounts from control and Vhl^−/− mice. Anti-CD31 was used as primary antibody (color spectrum = depth of blood vessels within the retina; ^*P < 0.05).