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. 2019 Jul 23;28(20):3339–3354. doi: 10.1093/hmg/ddz177

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Structure of the G194C-hE3 variant (PDB ID: 6I4P). (A and B) Cys194 is shown in (2mF_o-DF_c) composite omit map (2.0σ) in chains A and B, respectively. Based on indubitable difference densities, Cys194 could only be modeled with two alternative conformers in chain A (A). Active site disulfide and FAD (raspberry) are represented with sticks. (C) Active and substitution sites are shown in the superimposed structures of G194C-hE3 (dark teal; FAD: raspberry) and hE3 (beige; FAD: beige) in chain A. Cartoons are semitransparent and peptide segment 160–180 was removed for clarity.