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. 2020 Jun 2;11(22):2106–2119. doi: 10.18632/oncotarget.27609

Table 2. Characteristics and biological functions of the extracellular serum miRNAs modulated by physical activity.

miRNA Fold variation P value Biological function Tissue specificity Drug modulation References
miRNA-25 2.65 ↓ 0.0210 Dicer regulation; Oncogene (PTEN) suppression; calcium accumulation in mitochondria; apoptosis; mitochondrial function; suppression of colon cancer cells proliferation; oncogene (SMAD 7/ TGF β) suppression [41]
miRNA-30c 2.25 ↓ 0.0235 Protein repair; cell proliferation; stem cell recruitment; multi-drug resistant; stress (NFkB) response; oncogene (BCL9) suppression Lung Modulated by Metformin in mouse lung [33, 34]
Breast
Ovary
miRNA-92b 2.16 ↓ 0.0495 Dicer regulation; cell proliferation; apoptosis; Oncogene (PTEN) suppression Lung [43]
miRNA-133b 2.01 ↓ 0.0269 Muscle response to physical activity; associated with heart failure; oncogene (EGF) suppression; cell proliferation; cancer invasion Skeletal muscle
Heart
miRNA-204 4.08 ↓ 0.0170 Epithelial mesenchymal transition; apoptosis; cell proliferation; oncogene (VHL) suppression; removal of cancer cells by mitochondrial driver autophagy; regulation of autophagy induced by ischemia-reperfusion in heart (rat) [40, 44]
miRNA-206 2.21 ­↑ 0.0297 Muscle response to physical activity; associated with breast cancer prognosis and patients survival; oncogene (Wnt) suppression; cell proliferation; cardiac regeneration; inhibition of cancer invasion; metalloprotease (TIMP-3) inhibition Skeletal muscle [33, 36]
Breast
miRNA-450a 2.22 ↓ 0.0048 Heart Decreased in heart of diabetic mice [8]
miRNA-492 2.56 ↓ 0.0110 Angiogenesis Blood vessels (endothelium) [46]
miRNA-513b 2.11 ↓ 0.0378 Inflammation; apoptosis Lymphoma
miRNA-516b 2.56 ↓ 0.0053 Metastasis suppressor Melanoma [12]
miRNA-519e 2.22 ↓ 0.0078 Cell proliferation; Oncogene (HuR) suppression [45]
miRNA-711 3.14 ↓ 0.0277 Inhibition of heart fibrosis after heart infarction Modulated by Pioglitazone in rat heart [39]
miRNA-765 2.13 ↓ 0.0396 Oncogenic protein (HMGA1) suppression Prostate [47]
miRNA-877 2.06 ↓ 0.0163 Hepatocellular carcinoma Pioglitazone (2,10 up regulation in mouse lung)