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. 2019 Jan 28;28(10):1738–1751. doi: 10.1093/hmg/ddz012

Figure 5.

Figure 5

Mechanisms of impaired osteoclastogenesis in 4-week-old WT, mdx, dKO-Het and dKO-Hom mice. (A) TRAP staining of osteoclasts from 4-week-old mice after 7 days of culture. (B) Quantification of osteoclast gene expression at day 5 of osteoclastogenesis culture. Mdx, dKO-Het and dKO-Hom mice showed a trend toward decreased osteoclastogenesis compared to WT mice; however, these differences were not found to be statistically significant. (C) Serum RANKL was significantly decreased in mdx, dKO-Het and dKO-Hom mice compared to WT mice. (D) Serum SOST was significantly increased in dKO-Hom mice compared to WT control mice. Mdx mice also showed increased serum SOST levels relative to WT mice. *P < 0.05, **P < 0.01, ***P < 0.001.