Table 6.

Associations between independent variables and outcomes. All outcomes were analysed in separate multivariable regression models as described in the “Methods” section. Morbidity outcomes were reported for the first 28 days after admission

Outcome	Age	SAPS 3a	iGAS
Severe sepsis or septic shock, n = 1021
Mortality, CIb of HRc	1.002–1.016*	1.032–1.044*	0.204–0.746*
DAFd vasopressor, CIb of ORe	0.994–1.015	1.044–1.07*	0.897–3.681
DAFd ventilator CIb of ORe	0.977–0.997*	1.046–1.070*	0.694–2.330
CRRTf, CIb of ORe	0.979–1.002	1.031–1.054*	0.862–3.416
AKIN-creag, CIb of ORe	0.985–1.003	1.030–1.050*	1.246–4.968*

^aSimplified Acute Physiology Score 3

^bConfidence interval (95%)

^cHazard ratio

^dDays alive and free

^eOdds ratio

^fContinuous renal replacement therapy

^gAcute Kidney Injury Network (AKIN)-creatinine class 1 or worse

*p ≤ 0.05