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. 2020 Jun 3;40(23):4457–4468. doi: 10.1523/JNEUROSCI.0163-20.2020

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Figure 5. — Tg(myo6b:tmc2b-mEGFP-pA) expression rescues vestibular function in tmc1/2a/2b triple-mutant larvae (5 dpf). A, Side view of lateral cristae. Tmc2b-mEGFP localizes to hair bundles and rescues FM 4-64 hair-cell labeling in the tmc1/2a/2b triple mutants (WT, n = 7; mutant, n = 8). Scale bar, 5 μm. B, Tmc2b-mEGFP rescues the VIEM deficit in tmc1/2a/2b triple mutants (mutant = 0.099 ±.0.057 AU; mutant with transgene = 1.26 ± 0.35 AU; t = 6.6; df = 3.1). C, Tmc2b-mEGFP rescues FM 4-64 hair-cell labeling in mutant tmc1/2a/2b anterior maculae (side view) (WT, n = 7; mutant, n = 7). Scale bar, 5 μm.