The mRNA expression of pro-inflammatory cytokines and a chemokine in the striatum and mPFC in cocaine self-administered and control mice (n = 4). Brain tissues containing striatum or PFC from mice receiving saline (n = 4) or cocaine (n = 4) were examined for the expression of the pro-inflammatory cytokines il1β, il6, tnfα, and ccl2. (A - D) The expression levels of il1β, il6, tnfα, and ccl2 in NAc of cocaine self-administered and control mice. (E- H) The expression levels of il1β, il6, tnfα, and ccl2 in mPFc of cocaine self-administered and control mice.