Table 3.
PROMIS domain scores across disease severity spectrum
| Stage 1/2 Mean (SD) | Stage 3/4 Mean (SD) | p-value | Cohen’s d | |
|---|---|---|---|---|
| Pain Interference | 50.5 (11.1) | 51.2 (11.0) | 0.8 | 0.07 |
| Depression | 52.3 (9.5) | 54.1 (9.2) | 0.5 | 0.20 |
| Physical Function** | 42.6 (10.5) | 36.8 (10.4) | 0.04 | 0.56 |
| Social Roles*** | 51.5 (9.5) | 43.7 (10.9) | <0.001 | 0.76 |
| Fatigue | 53.2 (12.2) | 58.0 (11.9) | 0.1 | 0.40 |
| Anxiety | 54.8 (8.9) | 55.9 (8.9) | 0.6 | 0.13 |
| Sleep Disturbance | 49.4 (8.5) | 53.6 (10.8) | 0.1 | 0.43 |
| Global Physical Health** | 45.9 (12.5) | 39.5 (11.3) | 0.05 | 0.54 |
| Global Mental Health** | 51.6 (10.1) | 45.9 (8.0) | 0.02 | 0.63 |
| No Cardiac AL Mean (SD) | Cardiac AL Mean (SD) | p-value | Cohen’s d | |
|---|---|---|---|---|
| Pain Interference | 54.5 (11.5) | 49.6 (10.3) | 0.1 | 0.44 |
| Depression | 51.7 (8.6) | 54.3 (9.5) | 0.3 | 0.30 |
| Physical Function** | 44.0 (10.3) | 37.7 (10.6) | 0.03 | 0.60 |
| Social Roles | 49.0 (11.2) | 46.0 (10.7) | 0.3 | 0.27 |
| Fatigue | 52.6 (13.0) | 57.1 (11.6) | 0.2 | 0.36 |
| Anxiety | 54.4 (7.5) | 56.1 (9.4) | 0.5 | 0.19 |
| Sleep Disturbance* | 48.4 (10.2) | 53.6 (9.4) | 0.07 | 0.53 |
| Global Physical Health | 45.1 (12.7) | 41.1 (11.7) | 0.3 | 0.32 |
| Global Mental Health | 50.2 (10.5) | 47.6 (8.7) | 0.3 | 0.27 |
| 1 Organ Mean (SD) | 2 Organs Mean (SD) | 3+ Organs Mean (SD) | Overall p-value | 1 vs. 3 p (Cohen’s d) | 2 vs. 3 p (Cohen’s d) | |
|---|---|---|---|---|---|---|
| Pain Interference* | 51.3 (10.0) | 47.7 (8.7) | 56.8 (13.4) | 0.08 | 0.1 (0.47) | 0.01 (0.80) |
| Depression | 53.6 (9.0) | 52.0 (9.3) | 55.4 (9.5) | 0.6 | 0.6 (0.20) | 0.3 (0.36) |
| Physical Function** | 43.6 (9.4) | 39.8 (11.1) | 34.4 (10.6) | 0.04 | 0.01(0.92) | 0.1 (0.50) |
| Social Roles** | 49.7 (9.7) | 49.3 (9.9) | 39.9 (11.2) | 0.02 | 0.01 (0.94) | 0.01 (0.89) |
| Fatigue* | 52.3 (11.8) | 54.8 (12.2) | 61.3 (11.2) | 0.08 | 0.03 (0.78) | 0.1 (0.55) |
| Anxiety | 55.6 (9.1) | 53.9 (9.0) | 57.8 (7.9) | 0.4 | 0.4 (0.26) | 0.2 (0.47) |
| Sleep Disturbance | 49.4 (10.1) | 52.1 (9.4) | 54.7 (10.3) | 0.3 | 0.1 (0.52) | 0.4 (0.26) |
| Global Physical Health*** | 45.8 (12.1) | 44.2 (11.8) | 35.0 (9.7) | 0.01 | <0.01(0.98) | 0.01(0.85) |
| Global Mental Health*** | 50.1 (8.8) | 51.0 (9.4) | 42.2 (7.5) | <0.01 | <0.01(0.98) | <0.01 (1.03) |
Fatigue is derived from Fatigue 8a
Cohen’s d is a measure of effect size: d=0.2–0.49- weak, 0.5–0.79- medium, and >0.8- large effect sizes
Domains and summary scores are marked significant for exploration:
*
p <0.1,
**
p <0.05,
***
p <0.01
Bolded domains and summary scores are ones with p-value <0.5 and effect size >0.5