Table 3:

Cox regression analysis for all-stage LUAD TCGA patients

	Univariable analysis				Multivariable analysis
	Overall survival		Progression-free survival		Overall survival		Progression-free survival
Covariate	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
16q cluster status (16qMC+ vs. −)	1.84 (1.23–2.74)	0.003	1.30 (0.86–1.96)	0.214	1.95 (1.31–2.91)	0.001	1.30 (0.86–1.97)	0.207
Gender (Female vs. Male)	0.95 (0.71–1.27)	0.713	0.95 (0.72–1.26)	0.730
Pathologic stage (I/II vs. III/IV)	0.37 (0.27–0.51)	<0.001	0.62 (0.45–0.86)	0.004	0.36 (0.27–0.50)	<0.001	0.62 (0.45–0.86)	0.004
Smoking history (Smoker vs. non)	0.91 (0.60–1.39)	0.676	0.96 (0.65–1.44)	0.859
Mutation count (High vs. low)	0.98 (0.73–1.31)	0.893	0.94 (0.71–1.24)	0.669
Age at diagnosis	1.01 (0.99–1.02)	0.349	1.00 (0.98–1.01)	0.695