Table 3.
Effect modification between diabetes and pre-diabetes with high IFN-gamma TB antigen (≥10 IU/mL) among strata of tuberculin skin test results, N=513
| Effect of diabetes status on TB antigen within levels of TST** | Mean antigen, lU/mL (95%CI) | Mean TST induration, mm (95%CI) | TB antigen ≥10 IU/mL % (95%CI) | Crude odds ratio ≥10 IU/mL (95%CI) | Adjusted odds ratio* ≥10 IU/mL (95%CI) |
|---|---|---|---|---|---|
| TST positive, N=208 (induration ≥10 mm) | |||||
| Diabetes | 5.3 (3.6, 7.0) | 15.2 (14.1, 16.2) | 34.1 (17.1, 51.1) | 1.4 (0.5, 3.7) | 1.4 (0.5, 3.5) |
| Pre-diabetes | 5.9 (4.6, 7.1) | 15.7 (15.1, 16.2) | 41.2 (26.9, 55.4) | 1.8 (0.8, 4.0) | 1.7 (0.7, 4.1) |
| Euglycemic | 5.1 (4.1, 6.1) | 16.2 (15.5, 17.0) | 27.5 (18.1, 37.0) | REF | REF |
| TST negative, N=202 (induration <10mm) | |||||
| Diabetes | 3.3 (2.0, 4.6) | 1.9 (0.8, 2.9) | 14.0 (0.7, 27.2) | 3.6 (0.8, 16.4) | 4.8 (1.0, 22.0) |
| Pre-diabetes | 2.2 (1.3, 3.1) | 2.0 (0.9, 3.2) | 6.9 (0.0, 14.0) | 1.6 (0.4, 7.2) | 1.7 (0.4, 7.0) |
| Euglycemic | 1.7 (1.2, 2.2) | 1.5 (0.6, 2.3) | 4.3 (0.2, 8.5) | REF | REF |
| TST not done, N=103 (QFT positive) | |||||
| Diabetes | 3.9 (1.9, 5.8) | NA | 20.6 (2.2, 39.0) | 2.9 (0.4, 20.0) | 4.0 (0.6, 29.1) |
| Pre-diabetes | 5.0 (3.6, 6.4) | NA | 18.7 (7.7, 29.8) | 2.6 (0.6, 10.9) | 2.2 (0.4, 10.9) |
| Euglycemic | 3.1 (1.4, 4.7) | NA | 8.2 (0.0, 18.0) | REF | REF |
Table 3 Abbreviations TST: tuberculin skin test; QFT: QuantiFERON®-TB Gold-In-Tube
*
Adjusted for age, sex, history of active TB
**
Likelihood ratio p-value for interaction term between TST status and diabetes status =0.63
Bold indicates 95% confidence interval estimate did not include null value