Table 2.
Multivariate Cox proportional hazards regression analysis for recurrence-free survival (RFS) in the training cohort.
Variables | Univariate analysis | P value | Multivariate analysis | P value |
---|---|---|---|---|
OR (95% CI) | Adjusted OR (95% CI) | |||
Age (years) | ||||
<60 | 1 (referent) | |||
≥60 | 2.4 (1.3–4.3) | 0.003 | ||
| ||||
Depth of myometrial invasion | ||||
<50% | 1 (referent) | |||
≥50% | 2.9 (1.6–5.2) | <0.001 | ||
| ||||
Cervical stromal invasion | ||||
No | 1 (referent) | |||
Yes | 4.1 (2.2–7.6) | <0.001 | ||
| ||||
Histological grade | ||||
Grade 1/2 | 1 (referent) | 1 (referent) | ||
Grade 3 | 9.4 (5.0–18.0) | <0.001 | 4.2 (2.1–8.4) | <0.001 |
| ||||
Histological type | ||||
Type I | 1 (referent) | |||
Type II | 8.5 (4.7–15.2) | <0.001 | ||
| ||||
Tumor diameter | ||||
<2 cm | 1 (referent) | 1 (referent) | ||
≥2 cm | 6.6 (2.4–18.4) | <0.001 | 2.9 (1.0–8.4) | 0.049 |
| ||||
LVSI | ||||
No | 1 (referent) | |||
Yes | 4.1 (2.2–7.5) | <0.001 | ||
| ||||
FIGO stage | ||||
I | 1 (referent) | 1 (referent) | ||
II | 5.4 (2.0–14.3) | 0.001 | 2.4 (0.9–6.7) | 0.099 |
III | 8.8 (4.1–19.0) | <0.001 | 4.2 (1.9–9.5) | <0.001 |
IV | 84.3 (36.3–195.5) | <0.001 | 15.1 (5.4–42.8) | <0.001 |
| ||||
Peritoneal cytology | ||||
No | 1 (referent) | 1 (referent) | ||
Yes | 10.1 (5.6–18.3) | <0.001 | 2.5 (1.2–5.0) | 0.013 |
| ||||
Lymph node involvement | ||||
No | 1 (referent) | |||
Yes | 8.1 (4.2–15.5) | <0.001 | ||
| ||||
Lymphadenectomy | ||||
No | 1 (referent) | |||
Yes | 0.7 (0.3–1.4) | 0.27 | ||
| ||||
Adjuvant therapy | ||||
No adjuvant therapy | 1 (referent) | |||
Radiotherapy | 9.6 (2.0–45.6) | 0.004 | ||
Chemotherapy | 6.7 (3.0–14.7) | <0.001 | ||
Radiotherapy + chemotherapy | 5.3 (2.0–14.1) | <0.001 |
OR = odds ratio; CI = confidence interval; LVSI = lymphovascular space involvement; FIGO = International Federation of Gynecology and Obstetrics.