Table 2.
Multivariate Cox proportional hazards regression analysis for recurrence-free survival (RFS) in the training cohort.
| Variables | Univariate analysis | P value | Multivariate analysis | P value |
|---|---|---|---|---|
| OR (95% CI) | Adjusted OR (95% CI) | |||
| Age (years) | ||||
| <60 | 1 (referent) | |||
| ≥60 | 2.4 (1.3–4.3) | 0.003 | ||
|
| ||||
| Depth of myometrial invasion | ||||
| <50% | 1 (referent) | |||
| ≥50% | 2.9 (1.6–5.2) | <0.001 | ||
|
| ||||
| Cervical stromal invasion | ||||
| No | 1 (referent) | |||
| Yes | 4.1 (2.2–7.6) | <0.001 | ||
|
| ||||
| Histological grade | ||||
| Grade 1/2 | 1 (referent) | 1 (referent) | ||
| Grade 3 | 9.4 (5.0–18.0) | <0.001 | 4.2 (2.1–8.4) | <0.001 |
|
| ||||
| Histological type | ||||
| Type I | 1 (referent) | |||
| Type II | 8.5 (4.7–15.2) | <0.001 | ||
|
| ||||
| Tumor diameter | ||||
| <2 cm | 1 (referent) | 1 (referent) | ||
| ≥2 cm | 6.6 (2.4–18.4) | <0.001 | 2.9 (1.0–8.4) | 0.049 |
|
| ||||
| LVSI | ||||
| No | 1 (referent) | |||
| Yes | 4.1 (2.2–7.5) | <0.001 | ||
|
| ||||
| FIGO stage | ||||
| I | 1 (referent) | 1 (referent) | ||
| II | 5.4 (2.0–14.3) | 0.001 | 2.4 (0.9–6.7) | 0.099 |
| III | 8.8 (4.1–19.0) | <0.001 | 4.2 (1.9–9.5) | <0.001 |
| IV | 84.3 (36.3–195.5) | <0.001 | 15.1 (5.4–42.8) | <0.001 |
|
| ||||
| Peritoneal cytology | ||||
| No | 1 (referent) | 1 (referent) | ||
| Yes | 10.1 (5.6–18.3) | <0.001 | 2.5 (1.2–5.0) | 0.013 |
|
| ||||
| Lymph node involvement | ||||
| No | 1 (referent) | |||
| Yes | 8.1 (4.2–15.5) | <0.001 | ||
|
| ||||
| Lymphadenectomy | ||||
| No | 1 (referent) | |||
| Yes | 0.7 (0.3–1.4) | 0.27 | ||
|
| ||||
| Adjuvant therapy | ||||
| No adjuvant therapy | 1 (referent) | |||
| Radiotherapy | 9.6 (2.0–45.6) | 0.004 | ||
| Chemotherapy | 6.7 (3.0–14.7) | <0.001 | ||
| Radiotherapy + chemotherapy | 5.3 (2.0–14.1) | <0.001 | ||
OR = odds ratio; CI = confidence interval; LVSI = lymphovascular space involvement; FIGO = International Federation of Gynecology and Obstetrics.