Figure 2:

Network representation of genes (training and top candidate) and functionally enriched pathways in postoperative pain (PoP) and chronic postoperative pain (CPSP). Novel candidate genes for the phenotypes were identified using system biology-based approaches. Blue nodes represent biologic processes important to outcomes. Orange nodes represent training (known literature-curated) genes, and purple nodes represent novel candidate genes identified using system biology methodology likely to be associated with biologic process important to outcomes. This network is remarkable for the overlapping pathways underlining the complicated genetic architecture of acute postsurgical pain and its maintenance.