Fig. 4.

FTY720 attenuated the severity of pathogenic morphology in target organs of GvHD. Histopathology of the skin, liver and large and small intestine after BMT; the micrographs are from 1 of 2 independent experiments. The sections were stained with H&E (original magnification ×200). Epithelial loss, crypt damage, goblet cell depletion, and inflammatory cell infiltration were histologically scored. Bars represent the average histopathology scores of the skin, liver and large and small intestine, of each groups. Tissues were collected on day 28 after transplantation