Table 1.

Significant linear age dependence of local brain metabolite concentrations and spectral linewidths

ROI	NAA			Intercept		Slope		Decade variation
	N	R	p	Value	SD	Value	SD	%
MDd	52	−0.375**	0.006	10.04	0.57	−0.035	0.012	−3.80
MDv	52	−0.281*	0.043	9.25	0.53	−0.024	0.011	−2.71
fWM	52	−0.446**	0.001	10.46	0.48	−0.036	0.010	−3.72
HN	54	−0.272*	0.046	12.75	0.53	−0.023	0.011	−1.89
iCap	55	−0.372**	0.005	8.81	0.40	−0.025	0.009	−3.03
Putamen	55	−0.531**	0.000	10.32	0.47	−0.046	0.010	−4.91
pWM	55	−0.298*	0.027	10.47	0.44	−0.022	0.009	−2.15
Thalamus	54	−0.328*	0.016	8.49	0.36	−0.019	0.008	−2.39
Cho
CSO	53	0.342*	0.012	1.58	0.13	0.007	0.003	4.28
HN	55	0.394**	0.003	1.33	0.14	0.009	0.003	6.11
iCap	55	0.376**	0.005	1.27	0.12	0.008	0.003	5.37
SCC	53	0.316*	0.021	1.21	0.12	0.006	0.003	4.59
tCr
CSO	52	0.349*	0.011	5.70	0.45	0.026	0.010	4.19
Glx
Thalamus	53	−0.426**	0.001	8.52	0.55	−0.040	0.012	−5.13
ml
CSO	50	0.370**	0.008	3.37	0.54	0.033	0.012	8.18
Linewidth
Cbla	55	0.392**	0.003	7.12	0.66	0.044	0.014	5.47
CSO	55	0.376**	0.005	5.00	0.44	0.028	0.009	4.99
HN	55	0.394**	0.003	5.58	0.72	0.048	0.015	7.37
Putamen	55	0.481**	0.000	6.82	0.56	0.048	0.012	6.22
pWM	55	0.266*	0.049	5.46	0.46	0.020	0.010	3.42
SCC	55	0.487**	0.000	4.87	0.34	0.030	0.007	5.48
Thalamus	55	0.438**	0.001	5.29	0.57	0.043	0.012	7.06

^*Not significant but showing a tendency of age dependence (0.008 < p < 0.05)

^**Significant linear correlation (P < 0.008) Cbla cerebellar anterior lobe, MDd midbrain tegmentum, MDv cerebral peduncle, CSO centrum semiovale, fWM frontal white matter, HN subcortical hand motor area, iCap posterior limb of the internal capsule, pWM parietal white matter, SCC splenium of the corpus callosum, NAA N-acetylaspartate and N-acetylaspartylglutamate, Cho choline-containing compounds, tCr creatine and phosphocreatine, Glx glutamate and glutamine, mI myo-Inositol