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. 2020 Jun 2;12:4085–4096. doi: 10.2147/CMAR.S252962

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© 2020 Saffarzadeh et al.

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Expression of GRHL3 and PHLDA3 in association with clinicopathological features of HNSCC. Expression levels of GRHL3 (A) and PHLDA3 (B) were determined by qRT-PCR in different clinical stages of HNSCC tissue samples. The gender-based analysis showed that the expression levels of GRHL3 (C) and PHLDA3 (D) were significantly different in males and females. High HNSCC grade was associated with significant reduction of GRHL3 (E) and up-regulation of PHLDA3 (F). Patients with age of greater than 60 presented a down-regulation in the expression of GRHL3 (G) and up-regulation of PHLDA3 (H) expression level. The data represent the mean±SD of two replicates. *P<0.05; **P<0.01; ***P<0.001, ns, not significant.