Table 3.

Relative Expression of GRHL3 in HNSCC Tissues and Adjacent Tissues Based on Clinicopathological Features

Characteristics	Mean Difference	95.00% CI of Difference	Adjusted P-values	Significance
Gender
Normal (n=45) vs Male (n=33)	2.230	0.514 to 3.945	0.007	**
Normal (n=45) vs Female (n=12)	1.646	−0.785 to 4.078	0.24	ns
Male (n=33) vs Female (n=12)	−0.583	−3.107 to 1.939	0.845	ns
Age
Normal (n=45) vs >60 years (n=30)	2.06	0.292 to 3.827	0.018	*
Normal (n=45) vs <60 years (n=15)	2.104	−0.131 to 4.34	0.069	ns
>60 years (n=30) vs <60 years (n=15)	0.044	−2.326 to 2.416	0.998	ns
Smoking history
Normal (n=45) vs Yes (n=30)	2.137	0.370 to 3.904	0.013	*
Normal (n=45) vs No (n=15)	1.949	−0.286 to 4.184	0.100	ns
Yes (n=30) vs No (n=15)	−0.188	−2.559 to 2.182	0.980	ns
Histologic grade
Normal (n=45) vs Grade 1 (n=9)	−2.089	−5.213 to 1.034	0.303	ns
Normal (n=45) vs Grade 2 (n=15)	−2.561	−5.111 to −0.010	0.048	*
Normal (n=45) vs Grade 3 (n=21)	−2.811	−5.072 to −0.550	0.008	**
Grade 1 (n=9) vs Grade 2 (n=15)	−0.471	−4.079 to 3.135	0.986	ns
Grade 1 (n=9) vs Grade 3 (n=21)	−0.721	−4.130 to 2.686	0.94	ns
Grade 2 (n=15) vs Grade 3 (n=21)	−0.250	−3.142 to 2.642	0.995	ns
Pathologic stage
Normal (n=45) vs Stage 2 (n=18)	2.502	0.417 to 4.586	0.014	*
Normal (n=45) vs Stage 3 (n=27)	1.789	−0.030 to 3.609	0.054	ns
Stage 2 (n=18) vs Stage 3 (n=27)	−0.712	−2.987 to 1.561	0.736	ns

Notes: *P<0.05; **P< 0.01.

Abbreviation: ns, non-significant.