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. 2020 Jun 3;16:1391–1398. doi: 10.2147/NDT.S239504

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© 2020 Dudova et al.

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Model of targeting of CRMPs by maternal autoantibodies in MAR ASD. (A) Maternal autoantibodies targeting CRMPs readily pass placenta and (B) the undeveloped blood-brain barrier of the fetus. (C) The antibodies are internalized into neurons, bind and inactivate CRMPs resulting in changes in neural development.