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. Author manuscript; available in PMC: 2020 Jun 7.
Published in final edited form as: Am Soc Clin Oncol Educ Book. 2015:e50–e58. doi: 10.14694/EdBook_AM.2015.35.e50

TABLE 1.

Comparison of Breast Cancer Risk Factors in the Gail and Tyrer-Cuzick Models

Gail Model Tyrer-Cuzick Model
Age (35 or older) Age
Race/ethnicity (white, black, Hispanic, Asian American [Chinese, Japanese, Filipino, Hawaiian, other], unknown) Ashkenazi Jewish descent
Age at menarche Age at menarche
Age at first live birth Age at first live birth
Menopausal status
Age at menopause
Use of hormone replacement therapy
Body mass index
Number of benign breast biopsies
Benign breast biopsy with atypical hyperplasia (excludes LCIS, DCIS, or invasive breast cancer) Benign breast biopsy including hyperplasia with or without atypia and LCIS
Number of first-degree relatives with breast cancer Number of first-, second-, and third-degree relatives with breast or ovarian cancer, bilateral breast cancer, and age at diagnosis
BRCA mutation status

Abbreviations: DCIS, ductal carcinoma in situ; LCIS, lobular carcinoma in situ.