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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Feb 19;107(2):334–343. doi: 10.1016/j.ijrobp.2020.01.051

Table 3.

Definition/worksheet for the updated graded prognostic assessment for breast cancer patients with brain metastases (Breast GPA) and survival by GPA

Factor 0 0.5 1.0 1.5 Patient score
KPS ≤60 70–80 90–100 NA
Subtype Basal Luminal A NA HER2, Luminal B
Age ≤60 <60 NA NA
No. BM >1 1 NA NA
ECM Present Absent
Sum total =
GPA N (%) Median OS IQR
0.0–1.0 377 (19) 6.0 2.5–12.3
1.5–2.0 780 (39) 12.9 5.6–27.0
2.5–3.0 659 (33) 23.5 11.1–47.0
3.5–4.0 173 (9) 36.3 18.5–78.1

Abbreviations: BM = brain metastases; ECM = extracranial metastases; GPA = Graded Prognostic Assessment; HER2 = human epidermal receptor 2; IQR = interquartile range; KPS = Karnofsky Performance Status; OS = overall survival.