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. Author manuscript; available in PMC: 2020 Nov 18.
Published in final edited form as: Nat Genet. 2020 May 18;52(6):626–633. doi: 10.1038/s41588-020-0625-2

Extended Data Fig. 5. Relationship between expression cis-heritability and metrics of gene essentiality.

Extended Data Fig. 5

For each gene, pLI (probability of loss-of-function intolerance) was obtained from Lek et al. 2016 Nature and shet (selection against protein-truncating variants) was obtained from Cassa et al. 2017 Nature Genetics.