TABLE 2.
Measured and calculated blood gas, electrolyte and pH variables of eight healthy beagle dogs undergoing colloid fluid infusion for 120 min with 10 mL/kg/h of Gelofusine® (succinylated gelatin) or Voluven® (tetrastarch 130/0.4).
| Parameter | Treat | 0 | 60 | 120 | Ref interval | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | Min | Max | Mean | Min | Max | Mean | Min | Max | Min | Max | ||
| Sodium (mmol/L) | GEL | 147 | 144 | 156 | 147 | 144 | 154 | 145 | 142 | 151 | 142 | 151 |
| VOL | 147 | 144 | 150 | 145 | 143 | 149 | 145 | 143 | 148 | - | - | |
| Potassium (mmol/L) | GEL | 3.9* | 3.7 | 4.0 | 4.2* | 3.5 | 5.2 | 4.7* | 3.9 | 6.2 | 3.6 | 5.1 |
| VOL | 4.0* | 3.5 | 4.3 | 4.2* | 3.8 | 4.4 | 4.5* | 4.2 | 5.2 | - | - | |
| Chloride (mmol/L) | GEL | 114 | 112 | 119 | 114 | 112 | 118 | 114 | 112 | 118 | 107 | 117 |
| VOL | 113 | 110 | 115 | 114 | 111 | 116 | 114 | 112 | 116 | - | - | |
| Ionised calcium (mmol/L) | GEL | 1.3 | 1.2 | 1.3 | 1.2 | 1. | 1.3 | 1.3 | 1.2 | 1.3 | - | - |
| VOL | 1.3 | 1.3 | 1.3 | 1.2 | 1.2 | 1.3 | 1.3 | 1.2 | 1.3 | - | - | |
| PaO2 (mmHg) | GEL | 472 | 383 | 525 | 516 | 459 | 551 | 496 | 458 | 568 | - | - |
| VOL | 447 | 268 | 528 | 482 | 451 | 513 | 486 | 438 | 513 | - | - | |
| O2 content (mmol/L) | GEL | 25.8* | 25.0 | 27.0 | 22.7* | 20.0 | 26.0 | 21.0* | 19.0 | 25.0 | - | - |
| VOL | 24.5* | 19.0 | 28.0 | 22.8* | 19.0 | 27.0 | 22.1* | 19.0 | 26.0 | - | - | |
| SaO2 (%) | GEL | 99.8 | 99.8 | 99.9 | 99.8 | 99.7 | 99.9 | 99.8 | 99.7 | 99.9 | - | - |
| VOL | 99.8 | 99.7 | 99.9 | 99.8 | 99.7 | 99.9 | 99.8 | 99.7 | 99.9 | - | - | |
| PaCO2 (mmHg) | GEL | 53 | 48 | 60 | 52 | 42 | 67 | 47 | 37 | 56 | - | - |
| VOL | 50 | 45 | 60 | 52 | 45 | 62 | 50 | 43 | 61 | - | - | |
| CO2 content (mmol/L) | GEL | 26.6 | 24.2 | 28.6 | 26.2 | 23.0 | 30.1 | 25.6 | 21.1 | 29.0 | - | - |
| VOL | 26.1 | 21.0 | 30.1 | 26.2 | 21.8 | 29.3 | 26.3 | 21.9 | 29.7 | - | - | |
| pH | GEL | 7.29 | 7.24 | 7.33 | 7.29 | 7.24 | 7.35 | 7.33 | 7.30 | 7.36 | - | - |
| VOL | 7.31 | 7.25 | 7.40 | 7.29 | 7.23 | 7.40 | 7.31 | 7.24 | 7.42 | - | - | |
| HCO3- (actual) (mEq/L) | GEL | 25.0 | 22.7 | 26.9 | 24.5 | 21.5 | 28.1 | 24.0 | 19.9 | 27.2 | - | - |
| VOL | 24.5 | 19.6 | 28.3 | 24.6 | 20.2 | 27.9 | 24.7 | 20.4 | 27.8 | - | - | |
| HCO3- (standard) (mEq/L) | GEL | 22.3 | 20.7 | 23.5 | 22.1 | 19.7 | 24.2 | 22.6 | 20.2 | 24.4 | - | - |
| VOL | 22.3 | 18.6 | 26.5 | 22.2 | 18.2 | 26.7 | 22.5 | 18.5 | 26.9 | - | - | |
| BE (ECF) (mEq/L) | GEL | −1.7 | −4.3 | 0.3 | −2.2 | −5.7 | 0.7 | −2.1 | −5.9 | 0.9 | - | - |
| VOL | −2.0 | −7.6 | 2.7 | −2.1 | −7.6 | 3.0 | −1.8 | −7.3 | 3.0 | - | - | |
Treat, treatment; GEL, Gelofusine®; VOL, Voluven®; Min, minimum; Max, maximum; PaO2, partial pressure of oxygen; SaO2, arterial oxygen saturation; PaCO2, partial pressure of carbon dioxide; HCO3-, bicarbonate ion concentration; BE (ECF), base excess extra cellular fluid.
Variables are reported as mean values and range from immediately prior to initiation of infusion (time 0 min) for 120 min of infusion.
*
, p < 0.05 significant finding over time.