TABLE 3.
Haematological variables of eight healthy beagle dogs undergoing colloid fluid infusion for 120 min with 10 mL/kg/h of Gelofusine® (succinylated gelatin) or Voluven® (tetrastarch 130/0.4). Variables are reported as mean and range from immediately prior to initiation of infusion (time 0 min) and at the end of infusion (time 120 min).
| Parameter | Treat | 0 | 120 | Ref interval | |||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | Min | Max | Mean | Min | Max | Min | Max | ||
| Haemoglobin (g/L) | GEL | 168* | 144 | 191 | 140* | 128 | 160 | 120 | 180 |
| VOL | 162* | 128 | 186 | 143* | 124 | 164 | - | - | |
| Erythrocyte count (x 1012/L) | GEL | 7.2* | 6.0 | 8.0 | 6.0* | 5.4 | 7.2 | 5.5 | 8.5 |
| VOL | 7.1* | 5.9 | 8.5 | 6.2* | 5.6 | 7.5 | - | - | |
| Haematocrit (L/L) | GEL | 0.50* | 0.42 | 0.56 | 0.42* | 0.38 | 0.49 | 0.37 | 0.55 |
| VOL | 0.49* | 0.39 | 0.58 | 0.43* | 0.37 | 0.51 | - | - | |
| Mean corpuscular volume (fL) | GEL | 69.7 | 67.1 | 71.3 | 69.8 | 66.8 | 71.6 | 60 | 77 |
| VOL | 69.3 | 66.2 | 73.0 | 69.3 | 66.0 | 72.3 | - | - | |
| Mean corpuscular haemoglobin (pg) | GEL | 23.3 | 21.8 | 24.5 | 23.4 | 22.0 | 24.2 | - | - |
| VOL | 22.9 | 21.7 | 25.1 | 23.0 | 21.8 | 24.5 | - | ||
| Mean corpuscular haemoglobin concentration (g/dL) | GEL | 33.4 | 32.5 | 34.5 | 33.5 | 32.6 | 34.1 | 32 | 36 |
| VOL | 33.1 | 31.7 | 34.4 | 33.2 | 32.0 | 34.4 | - | - | |
| Red cell distribution width (%) | GEL | 12.9 | 11.9 | 14.0 | 12.9 | 12.0 | 13.9 | - | - |
| VOL | 12.9 | 12.2 | 13.8 | 12.8 | 12.2 | 13.7 | - | - | |
| Leukocyte count (×109/L) | GEL | 6.5* | 5.6 | 8.6 | 5.1* | 3.4 | 6.3 | 6 | 15 |
| VOL | 7.1* | 4.9 | 8.8 | 5.7* | 2.6 | 9.5 | - | - | |
| Neutrophil (Segmented) (×109/L) | GEL | 4.4* | 2.8 | 6.4 | 3.3* | 2.3 | 4.7 | 3 | 11.5 |
| VOL | 4.6* | 3.3 | 6.9 | 3.9* | 2.6 | 6.1 | - | - | |
| Neutrophil (Band) (×109/L) | GEL | 0.02 | 0.00 | 0.12 | 0.00 | 0.00 | 0.03 | 0 | 0.5 |
| VOL | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.09 | - | - | |
| Lymphocyte (×109/L) | GEL | 1.4 | 1.0 | 1.8 | 1.2 | 0.7 | 1.8 | 1 | 4.8 |
| VOL | 1.7 | 1.1 | 2.4 | 1.5 | 0.8 | 0.8 | - | - | |
| Monocyte (×109/L) | GEL | 0.28 | 0.06 | 0.49 | 0.22 | 0.05 | 0.42 | 0.15 | 1.35 |
| VOL | 0.33 | 0.08 | 0.70 | 0.21 | 0.09 | 0.47 | - | - | |
| Eosinophil (×109/L) | GEL | 0.50 | 0.28 | 0.89 | 0.37 | 0.09 | 1.28 | 0.1 | 1.25 |
| VOL | 0.40 | 0.18 | 0.75 | 0.26 | 0.14 | 0.39 | - | - | |
| Basophil (×109/L) | GEL | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0 | 0.1 |
| VOL | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | - | - | |
| Thrombocyte count (×109/L) | GEL | 263 | 83 | 371 | 238 | 181 | 299 | 200 | 500 |
| VOL | 346 | 171 | 526 | 341 | 187 | 511 | - | - | |
Treat, treatment; GEL, Gelofusine; VOL, Voluven; Min, minimum; Max, maximum; Ref, reference.
*
, p < 0.05 significant finding over time.