Table 3.
Univariate and Multivariate Cox Regression Analyses for Overall Survival in the Development Set
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age | 1.258 | 1.037–1.592 | 0.022 | 1.523 | 1.217–1.907 | 0.000 |
| Gender | 0.781 | 0.627–0.973 | 0.027 | 0.930 | 1.205–1.509 | 0.768 |
| NLR | 1.283 | 1.021–1.611 | 0.033 | 1.219 | 0.732–2.030 | 0.446 |
| PLR | 0.809 | 0.334–1.957 | 0.638 | 0.793 | 0.319–1.973 | 0.618 |
| Metastasis | 2.184 | 1.749–2.728 | 0.000 | 2.537 | 2.002–3.214 | 0.000 |
| Tumor site | 0.903 | 0.729–1.120 | 0.354 | 0.917 | 0.727–1.158 | 0.469 |
| Tumor size | 1.006 | 0.985–1.028 | 0.561 | 1.020 | 0.998–1.042 | 0.082 |
| ALP | 1.950 | 1.465–2.594 | 0.000 | 1.787 | 1.200–2.662 | 0.004 |
| Anti-angiogenesis therapy | 2.260 | 1.619–3.154 | 0.000 | 1.103 | 0.696–1.748 | 0.675 |
| CD4+/CD8+ ratio | 3.132 | 2.347–4.178 | 0.000 | 3.008 | 2.218–4.080 | 0.000 |
| Chemotherapy | 1.734 | 1.308–2.299 | 0.000 | 1.661 | 1.245–2.216 | 0.001 |
| CONUT score | 0.002 | 0.000 | ||||
| Normal | Ref | Ref | Ref | Ref | ||
| Mild+moderate | 1.186 | 0.722–1.950 | 0.501 | 1.657 | 0.994–2.761 | 0.053 |
| Severe | 1.788 | 1.068–2.994 | 0.027 | 2.597 | 1.527–4.417 | 0.000 |
Abbreviations: NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; ALP, alkaline phosphatase; CD, cluster of differentiation; HR, hazard ratio; Ref, reference; CONUT Score, controlling nutritional status score.