Table 1.
Comparative gene expression changes in human epidermal reconstructs (DHA versus UV) as performed and detected by Human Stress and Toxicity PathwayFinder™ PCR Array analysis specified in Fig. 5; all statistically significant changes detected in at least one treatment group are depicted (p < 0.05).
| Gene symbol |
gene description |
fold-change |
|
|---|---|---|---|
| [accession number] | UV | DHA | |
| CYP1A1 [NM_005260] | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 48.58 | ns |
| CYP2E1 [NM_024013] | Cytochrome P450, family 2, subfamily E, polypeptide 1 | 7.19 | ns |
| HSPA1A [NM_013371] | Heat shock 70 kDa protein 1A | 7.06 | 4.98 |
| CCL21 [NM_000757] | Chemokine (C–C motif) ligand 21 | 6.99 | ns |
| CYP7A1 [NM_000605] | Cytochrome P450, family 7, subfamily A, polypeptide 1 | 6.99 | ns |
| FASLG [NM_002187] | Fas ligand (TNF superfamily, member 6) | 6.99 | 1.95 |
| IL6 [NM_000600] | Interleukin 6 (interferon, beta 2) | ns | 6.35 |
| CCL4 [NM_058186] | Chemokine (C–C motif) ligand 4 | 6.13 | ns |
| NOS2 [NM_000595] | Nitric oxide synthase 2, inducible | 5.68 | ns |
| UGT1A4 [NM_003807] | UDP glucuronosyltransferase 1 family, polypeptide A4 | 5.64 | ns |
| IL1B [NM_000879] | Interleukin 1, beta | 4.67 | ns |
| HMOX1 [NM_022789] | Heme oxygenase (decycling) 1 | 4.60 | ns |
| CSF2 [NM_000557] | Colony stimulating factor 2 (granulocyte-macrophage) | 1.90 | 3.85 |
| HSPA5 [NM_012275] | Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) | 3.76 | ns |
| DNAJA1 [NM_002170] | DnaJ (Hsp40) homolog, subfamily A, member 1 | 3.64 | ns |
| FMO1 [NM_002188] | Flavin containing monooxygenase 1 | 3.38 | ns |
| LTA [NM_000880] | Lymphotoxin alpha (TNF superfamily, member 1) | 3.28 | ns |
| DNAJB4 [NM_002176] | DnaJ (Hsp40) homolog, subfamily B, member 4 | 3.02 | ns |
| HSPD1 [NM_018724] | Heat shock 60 kDa protein 1 (chaperonin) | 2.20 | 3.00 |
| PCNA [NM_002341] | Proliferating cell nuclear antigen | 2.77 | 5.25 |
| DDIT3 [NM_002169] | DNA-damage-inducible transcript 3 | ns | 2.82 |
| GSTM3 [NM_013278] | Glutathione S-transferase mu 3 (brain) | 2.75 | ns |
| HSPA2 [NM_000576] | Heat shock 70 kDa protein 2 | 2.61 | ns |
| HSPA6 [NM_014440] | Heat shock 70 kDa protein 6 (HSP70B′) | 2.46 | 5.30 |
| HSPA8 [NM_173205] | Heat shock 70 kDa protein 8 | 2.44 | ns |
| TNFRSF1A [NM_003809] | Tumor necrosis factor receptor superfamily, member 1A | 2.30 | 2.87 |
| UNG [NM_003326] | Uracil-DNA glycosylase | 2.27 | ns |
| MDM2 [NM_000584] | Mdm2 p53 binding protein homolog (mouse) | 2.25 | ns |
| CDKN1A [NM_005811] | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.12 | ns |
| XRCC2 [NM_001244] | X-ray repair complementing defective repair | 2.11 | 2.90 |
| EGR1 [NM_020124] | Early growth response 1 | ns | 2.13 |
| CHEK2 [NM_016204] | CHK2 checkpoint homolog (S. pombe) | 2.11 | 0.5 |
| NFKB1 [NM_003240] | Nuclear factor of kappa light polypeptide gene enhancer | 2.07 | ns |
| GADD45A [NM_000585] | Growth arrest and DNA-damage-inducible, alpha | 1.98 | ns |
| HSPE1 [NM_021803] | Heat shock 10 kDa protein 1 (chaperonin 10) | 2.00 | 1.98 |
| ERCC1 [NM_000641] | Excision repair cross-complementing, complementation group 1 | 2.00 | ns |
| CASP10 [NM_001718] | Caspase 10, apoptosis-related cysteine peptidase | 0.58 | 0.5 |
| ATM [NM_001200] | Ataxia telangiectasia mutated | 0.50 | ns |
| HSP90AA2P [NM_019618] | Heat shock protein 90 kDa alpha, class A member 2 | 0.49 | ns |
| HSPA1L [NM_000575] | Heat shock 70 kDa protein 1-like | 0.49 | ns |
| CCNC [NM_000639] | Cyclin C | 0.46 | 3.35 |
| ANXA5 [NM_006129] | Annexin A5 | 0.44 | ns |
| CASP8 [NM_001719] | Caspase 8, apoptosis-related cysteine peptidase | 0.42 | ns |
| SERPINE1 [NM_000594] | Serpin peptidase inhibitor, clade E, member 1 | 0.41 | ns |
| TNFSF10 [NM_003808] | Tumor necrosis factor (ligand) superfamily, member 10 | 0.40 | ns |
| TNF [NM_003701] | Tumor necrosis factor | 0.32 | 3.40 |
| RAD50 [NM_003239] | RAD50 homolog (S. cerevisiae) | 0.22 | ns |
| CCL3 [NM_000758] | Chemokine (C–C motif) ligand 3 | 0.03 | ns |
| BCL2L1 [NM_130851] | BCL2-like 1 | 0.01 | ns |