Table 2.
Crude and adjusted HRs and 95 % CIs for the associations between BMI and risk of ESCC and GC in the Linxian dysplasia population trial cohort.
| BMI (kg/m2) Normal (≥18.5 to <24.0) | Underweight (< 18.5) | Overweight or obese (≥24.0) | |
|---|---|---|---|
| ESCC | |||
| No. of cases | 495 | 121 | 34 |
| Crude HR (95 % Cl) | 1.00 | 1.28(0.87–1.87) | 0.66(0.47–0.93) |
| P-value | 0.089 | 0.018 | |
| Age- and gender-adjusted HR (95 % Cl) | 1.00 | 1.26(0.86–1.85) | 0.68(0.48–0.97) |
| P-value | 0.133 | 0.031* | |
| Multivariate adjusted HR (95 % CI)a | 1.00 | 1.22(0.82–1.78) | 0.69(0.48–0.98) |
| P-value | 0.098 | 0.035 | |
| GC b | |||
| No. of cases | 316 | 88 | 30 |
| Crude HR (95 % CI) | 1.00 | 1.08(0.71–1.63) | 0.91(0.62–1.32) |
| P-value | 0.843 | 0.603 | |
| Age- and gender-adjusted HR (95 % CI) | 1.00 | 1.02(0.80–1.29) | 1.06(0.73–1.55) |
| P-value | 0.881 | 0.753 | |
| Multivariate adjusted HR (95 % CI)a | 1.00 | 0.99(0.78–1.26) | 1.06(0.73–1.55) |
| P-value | 0.943 | 0.716 | |
P value derived from Cox regression analysis. Bold text indicates statistical significance. HR, hazard ratio. CI, confidence interval. BMI, body mass index. ESCC, esophageal squamous cell carcinoma. GC, gastric cancer.
a
Adjusted for age at baseline, gender, smoking, drinking, family history of cancer, education and consumption of fresh fruit.
b
Including gastric non-cardia carcinoma (GNCC) and cardia carcinoma (GCC).