Table 3.
Genes identified in the meta-analysis of FOS and MESA. Each row represents a gene transcript that was identified (FDR q < 0·05) in the meta-analysis of FOS and MESA trait-specific results. The identifiers corresponding to the transcript within each gene expression platform (MESA probe, FOS probeset, HeartBEAT Entrez Gene ID) are indicated. Meta-analysis p values and FDR q values are the original and the FDR q values, respectively, computed on the meta-analysis results of the relevant trait. HeartBEAT replication p values are one-sided p values guided by the direction of association in the meta-analysis. Sign is the direction of estimated association, with a positive (negative) sign representing higher (lower) expression with increasing trait value. Complete summary statistics from association analysis are provided in Supplementary files E5 (meta-analysis of FOS and MESA), and E6 (HeartBEAT). Fig. 2 visualizes the effect sizes for these transcripts in MESA and FOS for all investigated traits.
| MESA Probe | FOS Probeset | HeartBEAT Entrez Gene ID | Gene | Trait | Sign | Meta-Analysis p | Meta-Analysis FDR q | HeartBEAT replication p |
|---|---|---|---|---|---|---|---|---|
| ILMN_1708881 | 3525498 | 55647 | RAB20 | avgO2 | + | 1·93E-08 | 2·14E-04 | 0·046 |
| ILMN_2381257 | 3802980 | 1824 | DSC2 | avgO2 | – | 3·26E-07 | 1·78E-03 | 0·999 |
| ILMN_2397750 | 2448073 | 10625 | IVNS1ABP | minO2 | + | 5·51E-07 | 5·56E-03 | 0·144 |
| ILMN_1663119 | 3802980 | 1824 | DSC2 | avgO2 | – | 6·13E-07 | 2·27E-03 | 0·999 |
| ILMN_2235283 | 3954238 | 5594 | MAPK1 | minO2 | – | 9·52E-07 | 5·56E-03 | 0·830 |
| ILMN_1717877 | 2448073 | 10625 | IVNS1ABP | minO2 | + | 1·54E-06 | 5·78E-03 | 0·144 |
| ILMN_1702247 | 3591327 | 23582 | CCNDBP1 | AHI | + | 1·99E-06 | 2·43E-02 | 0·944 |
| ILMN_2046730 | 2435383 | 6281 | S100A10 | minO2 | – | 2·01E-06 | 5·87E-03 | 0·949 |
| ILMN_1678075 | 2892979 | 9425 | CDYL | avgO2 | – | 2·43E-06 | 5·44E-03 | 0·229 |
| ILMN_1747775 | 3478457 | 2054 | STX2 | avgO2 | + | 4·34E-06 | 6·86E-03 | 0·568 |
| ILMN_1796712 | 2435383 | 6281 | S100A10 | avgO2 | – | 4·86E-06 | 7·11E-03 | 0·949 |
| ILMN_2058251 | 3236958 | 7431 | VIM | avgO2 | – | 5·19E-06 | 7·25E-03 | 0·823 |
| ILMN_1768110 | 2515933 | 51776 | ZAK | avgO2 | – | 5·94E-06 | 7·53E-03 | 0·987 |
| ILMN_2230902 | 2830946 | 1495 | CTNNA1 | avgO2 | – | 6·91E-06 | 7·82E-03 | 0·847 |
| ILMN_1796712 | 2435383 | 6281 | S100A10 | minO2 | – | 7·35E-06 | 1·72E-02 | 0·949 |
| ILMN_2046730 | 2435383 | 6281 | S100A10 | avgO2 | – | 7·96E-06 | 8·08E-03 | 0·949 |
| ILMN_1765060 | 3536786 | 55030 | FBXO34 | avgO2 | – | 8·02E-06 | 8·09E-03 | 0·416 |
| ILMN_1656920 | 3554851 | 1396 | CRIP1 | minO2 | – | 1·67E-05 | 3·23E-02 | 0·198 |
| ILMN_1719433 | 2362157 | 912 | CD1D | avgO2 | + | 1·85E-05 | 1·68E-02 | 0·002 |
| ILMN_1755937 | 3627248 | 302 | ANXA2 | minO2 | – | 2·52E-05 | 4·21E-02 | 0·860 |
| ILMN_1782538 | 3236958 | 7431 | VIM | avgO2 | – | 3·41E-05 | 2·69E-02 | 0·823 |
| ILMN_1717163 | 2940202 | 2162 | F13A1 | avgO2 | – | 4·85E-05 | 3·41E-02 | 0·846 |
| ILMN_1810069 | 2525182 | 151195 | CCNYL1 | avgO2 | – | 5·38E-05 | 3·64E-02 | 0·950 |
| ILMN_2329679 | 3955915 | 8459 | TPST2 | avgO2 | – | 6·91E-05 | 4·21E-02 | 0·122 |
| ILMN_1769810 | 2628682 | 10550 | ARL6IP5 | avgO2 | – | 6·95E-05 | 4·22E-02 | 0·824 |
| ILMN_1703926 | 3535780 | 5732 | PTGER2 | avgO2 | – | 7·56E-05 | 4·42E-02 | 0·516 |
| ILMN_2366391 | 2410241 | 5052 | PRDX1 | avgO2 | – | 7·82E-05 | 4·50E-02 | 0·885 |
| ILMN_1717877 | 2448073 | 10625 | IVNS1ABP | avgO2 | + | 8·42E-05 | 4·67E-02 | 0·144 |