Table 4.
Therapeutic modalities and combinations
| Therapeutic modalities | IIIA (N=321) | IIIB (N 262) N=(%) | IIIA+IIIB (N=583) |
|---|---|---|---|
| Any combination | 207 (64.5) | 119 (45.4) | 326 (55.9) |
| Surgery | 119 (37.1) | 16 (6.1) | 135 (23.2) |
| Surgery alone | 9 (2.8) | 0 | 9 (1.5) |
| Surgery plus radiotherapy | 7 (2.2) | 1 (0.4) | 8 (1.4) |
| Surgery plus chemotherapy | 70 (21.8) | 7 (2.7) | 77 (13.2) |
| Preoperative chemotherapy | 22 (6.9) | 4 (1.5) | 26 (4.4) |
| Perioperative chemotherapy | 3 (0.9) | 0 | 3 (0.5) |
| Adjuvant chemotherapy | 45 (14.0) | 3 (1.1) | 48 (8.2) |
| Surgery plus RT plus CT (trimodality) | 33 (10.3) | 8 (3.1) | 41 (7.0) |
| Sequential preoperative RT plus CT | 2 (0.6) | 0 | 2 (0.3) |
| Concurrent preoperative RT plus CT | 3 (0.9) | 1 (0.4) | 4 (0.7) |
| Sequential postoperative RT plus CT | 23 (7.2) | 3 (1.1) | 26 (4.5) |
| Concurrent postoperative RT plus CT | 5 (1.6) | 4 (1.5) | 9 (1.5) |
| Thoracic RT (including other modalities) | 174 (54.2) | 144 (55.0) | 318 (54.6) |
| Radiotherapy alone | 37 (11.5) | 32 (12.2) | 69 (11.8) |
| Chemoradiotherapy | 97 (30.2) | 103 (39.3) | 200 (34.3) |
| Sequential | 74 (23.1) | 72 (27.5) | 146 (25.0) |
| Concurrent | 23 (7.2) | 31 (11.8) | 54 (9.3) |
| Chemotherapy (including other modalities) | 256 (79.7) | 212 (80.9) | 468 (80.3) |
| Chemotherapy alone | 58 (18.1) | 92 (35.1) | 150 (25.7) |
| Best supportive care alone | 9 (2.8) | 20 (7.6) | 29 (5.0) |
| Type of surgery | IIIA (N = 119) | IIIB (N = 16) | IIIA+IIIB (N = 135) |
| Lobectomy | 74 (62.3) | 3 (18.7) | 77 (57.0) |
| Bi-lobectomy | 6 (5.0) | 0 | 6 (4.5) |
| Pneumonectomy | 28 (23.5) | 4 (25.0) | 32 (23.7) |
| Atypical radical resection | 5 (4.2) | 1 (6.2) | 6 (4.5) |
| Non-radical surgery* | 6 (5.0) | 8 (50.0) | 14 (10.4) |
* = Non-radical surgery (n = 14) as biopsy (n = 4, all IIIB), exploration (n = 7, IIIA = 5, IIIB = 2) or palliative resection (n = 3, IIIA = 1, IIIB = 2); CT = chemotherapy; RT = radiotherapy