Table 7.

Overall survival according to diagnostic variables

					Survival
			Median	Univariate analysis	P-value	Multivariate analysis
Variable		N					P-value
			months (95% CI)	HR (95% Wald CI)		HR (95% Wald CI)
Stage	IIIA	321	20.0 (17.1; 21.4)		IIIA vs. IIIB:
	IIIB	262	14.4 (13.0; 15.9)	0.70 (0.58; 0.85)	< 0.001	0.77 (0.62;0.95)	0.017
Gender	Female Male	188 395	20.4 (16.8; 23.8) 15.4 (14.3; 17.6)	0.76 (0.62; 0.94)	Female vs . male: 0.010	0.78 (0.64;0.96)	0.044
Smoking	Current smoker	308	15.3 (14.2; 17.7)		Never-smokers	vs:
status	Former smoker	219	18.9 (15.9; 20.6)	Current: 0.54 (0.34; 0.84)	0.007	Current: 0.71 (0.42;0.22)	0.218
	Never smoker	42	27.1 (17.0; NA)	Former: 0.61 (0.39; 0.97)	0.036	Former: 0.75 (0.44;1.30)	0.308
Weight loss	No	406	20.0 (17.9; 21.1)		No vs. yes:
≥ 10%	Yes	120	12.7 (10.8; 14.8)	0.54 (0.43; 0.68)	< 0.001	0.68 (0.53;0.88)	0.003
		146	22.4 (17.7; 26.1)	0 vs. ≥ 2: 0.37 (0.28; 0.50)	< 0.001	0.62 (0.43;0.88)	0.007
PS		338	15.4 (13.9; 17.2)	1 vs. ≥ 2: 0.52 (0.41; 0.66)	< 0.001	0.69 (0.52;0.91)	0.009
	≥2	99	11.6 (8.8; 14.7)	0 vs. 1: 0.72 (0.57; 0.92)	0.007	0.90 (0.68;1.17)	0.422
	Squamous	309	16.3 (15.0; 19.0)		Adeno vs.:
Histology	Adenoca	220	18.1 (14.7; 20.6)	Squam: 0.96 (0.79; 1.18)	0.726	Squam: 0.93(0.68;1.26)	0.630
	NOS/others	54	15 (10.1; 20.1)	NOS/oth: 0.79 (0.57; 1.11)	0.18	NOS/oth:0.96(0.63;1.48)	0.857
EGFR	Positive	14	27.1 (20.3; NA)		Positive vs:
mutation	Negative	128	15.8 (13.9; 19.7)	Negative: 0.51 (0.24; 1.10)	0.087	Negative:0.57(0.25;1.28)	0.176
positivity	Not tested	441	16.5 (15.0; 18.9)	Not tested: 0.52 (0.25; 1.10)	0.087	Not tested:0.83(0.36;1.89)	0.651
Nodes	No	411	14.4 (13.3;15.9)		Yes vs. no:
confirmed	Yes	172	24.7 (21.0; 28.8)	0.56 (0.45; 0.70)	< 0.001	0.67 (0.52;0.87)	0.002
PET-CT or	Yes	163	19.6 (17.8; 22.8)		Yes vs. no:
PET scan	No	420	15.4 (14.1; 17.6)	0.73 (0.58–0.91)	0.005	0.84 (0.66;1.07)	0.160

NOS = not otherwise specified; oth = others; nodes confirmed = mediastinal lymph-nodes histologically confirmed; PS = performance status