Table 1.
Patient, cancer, and treatment characteristics by treatment modality (n = 79)
| Characteristic | Treatment modality |
P Value | |
|---|---|---|---|
| IMPT n = 33 (%) | IMRT n = 46 (%) | ||
| Mean age at diagnosis, y (SD) | 75.8 (6) | 69.3 (11) | <.01 |
| Sex | .50 | ||
| Male | 20 (61) | 24 (52) | |
| ECOG PS | .11 | ||
| 0 | 6 (18) | 19 (41) | |
| 1 | 19 (58) | 18 (39) | |
| 2 | 7 (21) | 6 (13) | |
| 3 | 1 (3) | 3 (7) | |
| Smoking status | .77 | ||
| Nonsmoker | 5 (15) | 9 (20) | |
| Former/current smoker | 28 (85) | 37 (80) | |
| Stroke | .51 | ||
| Absent | 33 (100) | 44 (96) | |
| Present | 0 (0) | 2 (4) | |
| Kidney disease | .71 | ||
| Absent | 29 (88) | 42 (91) | |
| Present | 4 (12) | 4 (9) | |
| Hypertension | .25 | ||
| Absent | 16 (49) | 29 (63) | |
| Present | 17 (52) | 17 (40) | |
| Coronary artery disease | .24 | ||
| Absent | 25 (76) | 40 (87) | |
| Present | 8 (24) | 6 (13) | |
| Diabetes mellitus | .71 | ||
| Absent | 29 (88) | 42 (91) | |
| Present | 4 (12) | 4 (9) | |
| Oxygen-dependent COPD | .02 | ||
| Absent | 27 (82) | 45 (98) | |
| Present | 6 (18) | 1 (2) | |
| Histology | <.01 | ||
| Adenocarcinoma | 12 (36) | 32 (70) | |
| Squamous cell carcinoma | 19 (58) | 12 (26) | |
| Large cell/neuroendocrine | 2 (6) | 2 (4) | |
| AJCC stage III or higher | .40 | ||
| I | 3 (9) | 0 | |
| II | 3 (9) | 4 (9) | |
| IIIA | 17 (52) | 25 (54) | |
| IIIB | 7 (21) | 13 (28) | |
| IV | 3 (9) | 4 (9) | |
| Total radiation dose, Gy | .19 | ||
| Median (range) | 60 (45-72) | 60 (54-66) | |
| Mean (SD) | 58 (6) | 60 (1) | |
| Concurrent chemotherapy | .34 | ||
| No | 14 (42) | 14 (30) | |
| Yes | 19 (58) | 32 (70) | |
| Reirradiation | .04 | ||
| No | 24 (73) | 42 (91) | |
| Yes | 9 (27) | 4 (9) | |
Abbreviations: AJCC = American Joint Committee on Cancer; COPD = chronic obstructive pulmonary disease; IMPT = intensity-modulated proton therapy; IMRT = intensity-modulated radiation therapy; SD = standard deviation.