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. 2020 Feb 21;10(5):825–836. doi: 10.1016/j.apsb.2020.02.005

Figure 4.

Figure 4

Reduction of HDAC1 protein in the liver of P50-KO mice. HDAC1 protein was decreased in the liver of P50-KO mice compared with that of WT mice. HDAC1 down-regulation was associated with the decrease in hepatic steatosis. (A) Nuclear protein in the liver tissue of P50-KO mice on chow diet. (B) Nuclear protein in the liver of P50-KO mice on HFD. (C) mRNA expression. mRNA level of HDAC1, HDAC3, SIRT1 was determined in the liver tissue of P50-KO mice on chow diet and HFD, respectively. (D) Proteins in liver tissue of WT mice on HFD. Western blot was performed for HDAC1, HDAC3, SIRT1, SCD1 and SREBP1 proteins in liver tissue of WT mice on HFD for 4 months. In the bar figure, each data represents mean ± SE (n = 8). *P < 0.05, **P < 0.01.