Figure 7.

Qualitative comparison between the sugar preferences of DC‐SIGN and langerin. The central area displays those epitopes similarly recognized by both receptors. To clarify, Gal has not been included as free sugar, as the dissociation constants are rather high in both cases. Only langerin recognizes sulfated moieties, including Gal and Glc, although it preferentially targets outer Man residues in complex glycans. Also, DC‐SIGN interacts with a wider range of fucosylated structures and more easily accommodates Man residues from highly branched scaffolds.