Figure 8.

Crystallographic models obtained for langerin interacting with different mono‐ and oligosaccharides. Sugars are colored as follows: Man: green, Fuc: magenta, Gal: yellow, Glc: blue. Residues A289, K299, K313, F315, and V351 are shown as sticks in all structures, other relevant amino acids are labeled in particular cases. A) Man₂ (PDB ID: 3P5F). B) Blood group B trisaccharide (PDB ID: 3P5G). C) 6S‐LacNAc (PDB ID: 3P5I). D) GlcNS6S (PDB ID: 5G6U). E) α‐OMe‐GlcNAc (PDB ID: 4N32); on the right is a mimetic scaffold based on the binding pose of GlcNAc, bearing an aromatic moiety to establish aliphatic contacts with nearby side chains (F315).