Table 1.
General information on the four C‐type lectins reviewed in this text.
|
Human C‐type lectin and oligomeric state |
Relevant interacting monosaccharides and glycans |
Murine orthologues and identity [%] for the CRD[b] |
Reported 3D‐structures by X‐ray crystallography or cryoEM |
|---|---|---|---|
|
DC‐SIGN (tetramer) |
Man, Fuc, High Man N‐glycans (inner Man), Le‐type, ABO antigens |
SIGNR1‐SIGNR5 (65–70 %), SIGNR6‐SIGNR8 |
1K9I, 2XR5, 2XR6, 1SL4, 1SL5, 2IT5, 2IT6, 6GHV, 2B6B (cryoEM) |
|
langerin (trimer) |
Man, Fucα1‐2, GlcNAc, 6SGal, High Man N‐glycans (outer Man), GAGs |
langerin (77 %) |
3C22, 5G6U, 3KQG, 3P7F, 3P7G, 3P7H, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37, 4N38, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I |
|
MGL (trimer) |
terminal GalNAc |
MGL1‐MGL2 (64–68 %) |
n.a. |
|
LSECtin (dimer)[a] |
|
LSECtin (71 %) |
n.a. |