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Relationship between Ca2+ release capacity and lipid droplet size. Relationship between twitch force (A) and tetanic force (B) in the extensor digitorum longus (EDL) muscle. C: average peak Ca2+ responses (Fluo-4 fluorescence) during twitch forces. D: time to peak (TTP) and lipid morphology size. Assessed by transmission electron microscopy (lipid droplet size). ΔF/F0, ratio of change in peak fluorescence intensity/prestimulation level; HFD, high-fat diet; LFD, low-fat diet.
