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. 2020 Apr 1;2(1):vdaa040. doi: 10.1093/noajnl/vdaa040

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© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Volcano plots of gene expression differences between patients and controls by CAC subset. Upper row (A–C): Volcano plots (−log10 P-value vs log2 fold change (FC) with the following cutoff values: FC > l1.25l, P < .5) of GBM versus MI CACs. More genes are overexpressed in GBM versus MI CACs. Overexpressed genes belong to all functional groups. Specifically, there is higher expression in GBM versus MI CACs (especially, HPCs and CD34⁺ cells) of growth factor receptors (GFRs), chemotactic receptors (CRs), and mobilization factors (MFs). There is higher expression in GBM versus MI HPCs of proangiogenic factors (PAFs). Z-scores and P-values of gene expression in GBM versus MI CACs are given in Figure 5. Middle row (D–F): Volcano plots (−log10 P-value vs log2 FC with the following cutoff values: FC > l1.25l, P < .5) of GBM versus HC CACs. A similar overall pattern of higher gene expression is seen as in the comparison of GBM versus MI CACs. Overexpressed genes belong to all functional groups. Higher expression in GBM versus HC CACs (especially, HPCs and CD34+ cells) of GFRs, CRs, MFs, adhesion factors (ITGs), PAFs. Lower row (G–I): Volcano plots (−log10 P-value vs log2 FC with the following cutoff values: FC > l1.25l, P < .5) of MI versus HC CACs. Overall gene expression is similar/lower in MI CACs versus HC CACs. Lower expression is seen in MI versus HC HPCs for PAFs, CRs, and MFs.