FIGURE 4.

Myeloid cell cytokine specific gene signatures are present and detectable in human whole blood. (A) Heatmaps of whole-blood scaled expression values from three separate healthy donors subjected to stimulation with IFN-β, IFN-γ, IFN-λ, IL-10, IL-13, and IL-4. The selected genes are color coded according to the gene expression patterns identified in our MCCS signature as shown in Fig. 3. (B) Gene expression by Nanostring of myeloid cell signature genes from whole blood stimulated with IFN-γ, IFN-β, or null (no stimulation) in 25 donors from the Milieu Interieur Consortium cohort (41). Significance was determined by Wilcox test with *p < 0.001. Macs, macrophages; Monos, monocytes.