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. 2020 May 8;204(12):3339–3350. doi: 10.4049/jimmunol.2000213

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Copyright © 2020 by The American Association of Immunologists, Inc.

This article is distributed under The American Association of Immunologists, Inc., Reuse Terms and Conditions for Author Choice articles.

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FIGURE 6. — IL-10 upregulation is not the exclusive mechanism of Δ9-THC anti-inflammatory effect in acute inflammation IL-10 signaling blocking does not fully abrogate anti-inflammatory effects of Δ9-THC (12-wk-old male, n = 2 + 8 + 10 + 10 + 5). *p < 0.05, ***p < 0.001, LPS + Δ9-THC + isotype versus LPS + vehicle + isotype. ^##p < 0.01, ^###p < 0.001, LPS + vehicle + isotype versus LPS + isotype + IL-10R Ab. ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001, LPS + Δ9-THC + isotype versus LPS + Δ9-THC + IL-10R Ab. Two-tailed Mann–Whitney U test at each time point.