Table 4.
Drug-drug interactions.
| Degree of interaction | Interacting combination | Frequency (%) | Consequences |
|---|---|---|---|
| Minor | Aspirin + frusemide | 4 (3.6) | Combination effect level of potassium in serum affects CYP3A4 enzyme in liver antagonize hypoglycemic effect |
| Dexamethasone + omeprazole | 2 (1.8) | ||
| Insulin + frusemide | 6 (5.5) | ||
| Moderate | Glimepiride + aspirin | 1 (0.9) | Hypoglycemia chances |
| Dexamethasone + aspirin | 1 (0.9) | Peptic ulceration chances | |
| Dexamethasone + clopidogrel | 1 (0.9) | Affects CYP3A4 enzyme in the liver | |
| Dexamethasone + insulin | 1 (0.9) | Antagonize hypoglycemic effect | |
| Major | Metformin + metformin | 1 (0.9) | Severe hypoglycemia chances |
| Heparin + aspirin + toradol | 1 (0.9) | Bleeding chances | |
| Dexamethasone + hydrocortisone | 1 (0.9) | Steroid toxicity chances (cushing syndrome) | |
| Dexamethasone + triamcinolone | 1 (0.9) | ||
| Total | 20 (18.1) |