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. 2020 Apr 30;10(5):697. doi: 10.3390/biom10050697

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CBS contributes to the maintenance of proliferation of colon cancer cells in vivo. The shRNA-mediated CBS silencing (shCBS) of HCT116 cells attenuates their growth rate after subcutaneous transplantation into nude mice. In contrast, silencing of CSE (shCSE) does not suppress the proliferation of HCT116 cells. Control HCT116 cells were subjected to a non-targeted (NT) shRNA sequence (shNT). * p < 0.05 shows significant inhibitory effect of CBS silencing. Reproduced by permission from [88].