Figure 1.

Box C/D snoRNPs. (A) Box C/D snoRNPs catalyze the methylation of the 2′ hydroxyl of RNA. This is thought to reduce the hydrophilic nature of the nucleotides and allow rRNA to be buried inside of the ribosome. (B) Secondary structure of a typical Box C/D snoRNA indicating the location of Box C/C′ (blue), Box D/D′ (green), and hybridized rRNA (red). Location of methylation is denoted as 5′ bps from Box D/D’. (C) Assemblage of protein factors on the snoRNA illustrates that SNU13 binds the K-turns which positions FBL at the site of methylation.