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. 2020 May 25;10(5):808. doi: 10.3390/biom10050808

Figure 3.

Figure 3

(A) DETA NONOate significantly reduced MMP-9 mRNA at high concentrations in cytokine-stimulated Caco-2 cells (## p < 0.01 vs. unstimulated Caco-2 cells (negative control); * p < 0.05 vs. cytokine-stimulated Caco-2 cells (positive control). (B) Measurements of nitrate and nitrite concentrations as breakdown products of NO by the Griess assay on the conditioned media of Caco-2 cells after 24 h of co-incubation with DETA-NONOate and pro-inflammatory cytokines TNF-α and IL-1β. Top left pane shows the nitrite concentration, top right panel shows the nitrate concentration, bottom left pane shows the combined reduced NO groups and bottom right shows the linear correlations of DETA-NONOate concentrations versus the concentration of measured NOx− species (*** p < 0.001 vs. negative control).