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内质网应激介导的KCs源性TNF-α分泌经上调TNFR/caspase8信号通路活性诱导LX2细胞凋亡
Endoplasmic reticulum stress-mediated TNF-α secretion in KCs induces apoptosis in LX2 cells by up-regulating TNFR/caspase8 signaling pathway activity. A: Immunofluorescence detection of M1 type KCs, ×400, *P < 0.05; B, C: TNF-α expression and mRNA levels in cell supernatant, *P < 0.05; D: Western blotting detects the expression of TNFR, cleaved caspase 8, cleaved caspase 3 in each group of KCs; E: Relative expression of protein. *P < 0.05.
