Table 3.
Allele and genotype frequencies of CYP3A4, CYP3A5 and UGT1A4 genes in BC patients.
| SNP Equilibrium | Therapy Group (n = 82) |
W/O Group (n = 44) |
Total | ** p-Value for Hardy–Weinberg Equilibrium |
|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||
| CYP3A4 | ||||
| *1A/*1A(A/A) | 76 (92.7) | 43 (97.7) | 119 (94) | 0.75 |
| *1A/*1B(A/G) | 6 (7.3) | 1 (2.3) | 7 (6) | |
| *1B/*1B(G/G) | 0 (0) | 0 (0) | 0 (0) | |
| CYP3A5 | ||||
| *1/*1(A/A) | 0 (0) | 0 (0) | 0 (0) | 0.48 |
| *1/*3(A/G) | 11 (13.4) | 4 (9.1) | 15 (12) | |
| *3/*3(G/G) | 71 (86.6) | 40 (90.9) | 111 (88) | |
| UGT1A4 | ||||
| *1/*1(C/C) | 59 (95.2) | 14 (100) | 73 (96.1) | 0.86 |
| *1/*2(A/C) | 3 (4.8) | 0 (0) | 3 (3.9) | |
| *2/*2(A/A) | 0 (0) | 0 (0) | 0 (0) |
** p-values express whether Croatian population is similar to respective populations.