Skip to main content
. 2020 May 22;17(10):3675. doi: 10.3390/ijerph17103675

Figure 1.

Figure 1

VPA significantly inhibits the proliferation of rat growth plate chondrocytes.Rat growth plate chondrocytes were treated daily with 60 μg/mL VPA, 7 μg/mL OXA, 37 μg/mL LEV, 5 μg/mL LTG, or 10 μg/mL TPM for 5 days. The proliferation of the chondrocytes was assessed by the MTT assay. Among the AEDs tested, rat chondrocytes significantly decreased 72.65 ± 6.68% in the VPA group (p = 0.0064) (n = 5, ** p < 0.01, compared with control). CON—control, culture medium; VEH—vehicle, 0.1% DMSO+culture medium; VPA—valproic acid, 60 μg/mL; LEV—levetiracetam, 37 μg/mL; OXA—oxcarbazepine, 7 μg/mL; LTG—lamotrigine, 5 μg/mL; and TPM—topiramate, 10 μg/mL.