Table III.
Meta-analysis of resveratrol supplementation on cardiometabolic risk factors
| Variable | N | Point estimate | Standard error | Lower limit | Upper limit | P-value | Q-value | d f (Q) |
P-value (Q) |
I2 |
|---|---|---|---|---|---|---|---|---|---|---|
| Overall: | ||||||||||
| CRP [mg/l] | 5 | –0.208 | 0.490 | –1.169 | 0.753 | 0.671 | 44.289 | 4 | 0.000 | 90.968 |
| DBP [mm Hg] | 7 | –0.006 | 0.235 | –0.466 | 0.454 | 0.980 | 20.879 | 6 | 0.002 | 71.263 |
| Glucose [mg/dl] | 13 | –0.330 | 0.328 | –0.973 | 0.313 | 0.315 | 126.431 | 12 | 0.000 | 90.509 |
| HDL-C [mg/dl] | 14 | 0.238 | 0.310 | –0.370 | 0.846 | 0.443 | 145.031 | 13 | 0.000 | 91.036 |
| HOMA-IR | 8 | –0.570 | 0.284 | –1.127 | –0.014 | 0.045 | 31.148 | 7 | 0.000 | 77.527 |
| Insulin [µIU/ml] | 10 | –0.134 | 0.226 | –0.576 | 0.309 | 0.554 | 33.846 | 9 | 0.000 | 73.409 |
| LDL-C [mg/dl] | 12 | –0.653 | 0.354 | –1.347 | 0.041 | 0.065 | 135.390 | 11 | 0.000 | 91.875 |
| SBP [mm Hg] | 8 | –0.414 | 0.265 | –0.932 | 0.105 | 0.118 | 31.818 | 7 | 0.000 | 78.000 |
| T-chol [mg/dl] | 14 | –0.624 | 0.341 | –1.291 | 0.044 | 0.067 | 171.272 | 13 | 0.000 | 92.410 |
| TG [mg/dl] | 12 | –0.078 | 0.370 | –0.804 | 0.648 | 0.834 | 136.418 | 11 | 0.000 | 91.937 |
| Metabolic syndrome: | ||||||||||
| CRP [mg/l] | 4 | –0.192 | 0.641 | –1.448 | 1.063 | 0.764 | 44.289 | 3 | 0.000 | 93.226 |
| DBP [mm Hg] | 3 | 0.119 | 0.417 | –0.698 | 0.936 | 0.775 | 10.274 | 2 | 0.006 | 80.533 |
| Glucose [mg/dl] | 4 | –1.559 | 0.733 | –2.996 | –0.122 | 0.033 | 43.228 | 3 | 0.000 | 93.060 |
| HDL-C [mg/dl] | 7 | 1.235 | 0.585 | 0.088 | 2.382 | 0.035 | 114.981 | 6 | 0.000 | 94.782 |
| HOMA-IR | 2 | –1.113 | 0.233 | –1.570 | –0.656 | 0.000 | 0.007 | 1 | 0.935 | 0.000 |
| Insulin [µIU/ml] | 2 | –0.576 | 0.582 | –1.716 | 0.565 | 0.323 | 5.642 | 1 | 0.018 | 82.277 |
| LDL-C [mg/dl] | 7 | –1.175 | 0.583 | –2.319 | –0.031 | 0.044 | 118.830 | 6 | 0.000 | 94.951 |
| SBP [mm Hg] | 4 | 0.047 | 0.237 | –0.417 | 0.510 | 0.844 | 5.704 | 3 | 0.127 | 47.404 |
| T-chol [mg/dl] | 7 | –1.898 | 0.725 | –3.318 | –0.477 | 0.009 | 159.099 | 6 | 0.000 | 96.229 |
| TG [mg/dl] | 6 | –0.744 | 0.771 | –2.256 | 0.768 | 0.335 | 133.582 | 5 | 0.000 | 96.257 |
| Obese healthy: | ||||||||||
| CRP [mg/l] | 1 | –0.263 | 0.318 | –0.885 | 0.360 | 0.408 | 0.000 | 0 | 1.000 | 0.000 |
| DBP [mm Hg] | 4 | –0.100 | 0.320 | –0.727 | 0.526 | 0.753 | 10.029 | 3 | 0.018 | 70.086 |
| Glucose [mg/dl] | 9 | 0.145 | 0.314 | –0.470 | 0.761 | 0.643 | 52.751 | 8 | 0.000 | 84.835 |
| HDL-C [mg/dl] | 7 | –0.289 | 0.284 | –0.845 | 0.268 | 0.309 | 26.859 | 6 | 0.000 | 77.661 |
| HOMA-IR | 6 | –0.381 | 0.337 | –1.042 | 0.280 | 0.259 | 21.849 | 5 | 0.001 | 77.115 |
| Insulin [µIU/ml] | 8 | –0.017 | 0.240 | –0.488 | 0.454 | 0.944 | 22.113 | 7 | 0.002 | 68.344 |
| LDL-C [mg/dl] | 5 | 0.027 | 0.235 | –0.433 | 0.487 | 0.907 | 8.427 | 4 | 0.077 | 52.536 |
| SBP [mm Hg] | 4 | –0.873 | 0.370 | –1.598 | –0.149 | 0.018 | 12.212 | 3 | 0.007 | 75.434 |
| T-chol [mg/dl] | 7 | –0.018 | 0.165 | –0.342 | 0.306 | 0.912 | 9.729 | 6 | 0.137 | 38.331 |
| TG [mg/dl] | 6 | 0.104 | 0.150 | –0.189 | 0.398 | 0.486 | 2.800 | 5 | 0.731 | 0.000 |
| Both male and female: | ||||||||||
| CRP [mg/l] | 4 | –0.192 | 0.641 | –1.448 | 1.063 | 0.764 | 44.289 | 3 | 0.000 | 93.226 |
| DBP [mm Hg] | 4 | –0.055 | 0.327 | –0.695 | 0.585 | 0.866 | 13.435 | 3 | 0.004 | 77.671 |
| Glucose [mg/dl] | 8 | –0.748 | 0.400 | –1.533 | 0.036 | 0.062 | 81.112 | 8 | 0.000 | 91.370 |
| HDL-C [mg/dl] | 10 | 0.608 | 0.375 | –0.128 | 1.344 | 0.105 | 117.445 | 10 | 0.000 | 92.337 |
| HOMA-IR | 3 | –0.668 | 0.265 | –1.187 | –0.149 | 0.012 | 4.055 | 2 | 0.132 | 50.677 |
| Insulin [µIU/ml] | 5 | –0.634 | 0.186 | –0.998 | –0.270 | 0.001 | 6.137 | 4 | 0.189 | 34.822 |
| LDL-C [mg/dl] | 9 | –0.876 | 0.453 | –1.763 | 0.012 | 0.053 | 123.867 | 9 | 0.000 | 93.541 |
| SBP [mm Hg] | 4 | –0.285 | 0.400 | –1.069 | 0.499 | 0.476 | 19.639 | 3 | 0.000 | 84.724 |
| T-chol [mg/dl] | 10 | –0.930 | 0.461 | –1.832 | –0.027 | 0.044 | 165.727 | 10 | 0.000 | 94.569 |
| TG [mg/dl] | 8 | –0.388 | 0.554 | –1.475 | 0.698 | 0.483 | 134.626 | 8 | 0.000 | 94.800 |
| Male: | ||||||||||
| CRP [mg/l] | 1 | –0.263 | 0.318 | –0.885 | 0.360 | 0.408 | 0.000 | 0 | 1.000 | 0.000 |
| DBP [mm Hg] | 2 | –0.269 | 0.331 | –0.917 | 0.379 | 0.415 | 1.561 | 1 | 0.212 | 35.923 |
| Glucose [mg/dl] | 4 | 0.847 | 0.804 | –0.730 | 2.424 | 0.293 | 33.894 | 3 | 0.000 | 91.149 |
| HDL-C [mg/dl] | 3 | –0.909 | 0.920 | –2.711 | 0.894 | 0.323 | 23.361 | 2 | 0.000 | 91.439 |
| HOMA-IR | 4 | –0.629 | 0.643 | –1.889 | 0.631 | 0.328 | 23.743 | 3 | 0.000 | 87.365 |
| Insulin [µIU/ml] | 4 | 0.507 | 0.407 | –0.291 | 1.306 | 0.213 | 10.872 | 3 | 0.012 | 72.407 |
| LDL-C [mg/dl] | 2 | 0.418 | 0.253 | –0.078 | 0.914 | 0.098 | 0.375 | 1 | 0.540 | 0.000 |
| SBP [mm Hg] | 3 | –0.825 | 0.417 | –1.642 | –0.009 | 0.048 | 5.797 | 2 | 0.055 | 65.500 |
| T-chol [mg/dl] | 3 | 0.057 | 0.224 | –0.382 | 0.495 | 0.801 | 0.092 | 2 | 0.955 | 0.000 |
| TG [mg/dl] | 3 | 0.243 | 0.225 | –0.198 | 0.685 | 0.280 | 1.213 | 2 | 0.545 | 0.000 |
SE – standard error, N – number of studies.