Figure 6.

Association of tissue ceramide, LPC and LPE fatty acid chain lengths with gastroesophageal junction tissue pathology. (a–c) Total chain length plots for tissue lipids, showing the alterations in log2 abundances between the disease condition and control. The x-axis labels refer to the total fatty acid chain length of the measured lipid. The disease conditions metaplasia and inflammation were visualized after applying the removeBatchEffect function from the limma R package. Positive values represent lipids that are more abundant in the disease condition group than in the control group. The metrics shown in the plots refer to the Pearson correlation coefficient (R) and p-value. The smoothed line and 95% confidence interval were drawn using geom_smooth, by fitting a linear model. The structures above each plot represent lipid species of the Ceramide, LPC and LPE classes, where the R groups refer to the hydrocarbon chains of varying lengths.