Table 2.
Selectivity indices (SI) of compounds determined for S. aureus (MRSA) ATCC 43300 and C. neoformans var grubii H99 ATCC 208821, in relation to CC50 (concentration (μg/mL) of 50% cytotoxicity) against HEK293 and HC10 (concentration (μg/mL) of 10% haemolysis of human red blood cells).
| Selectivity Index (SI) | ||||
|---|---|---|---|---|
| Cmpd | S. aureus (MRSA) | C. neoformans | ||
| CC50/MIC | HC10/MIC | CC50/MIC | HC10/MIC | |
| 1 | 3.0 | 1.0 | 23.8 | 7.8 |
| 2 | 12.4 | 1.8 | >49.6 | >7.2 |
| 3 | 0.4 | >2 | 12.0 | >64 |
| 4 | 0.5 | 0.2 | >66.4 | >22.4 |
| 5 | 0.2 | 0.4 | 2.9 | 5.6 |
| 6 | 0.6 | 1.0 | 1.1 | 2.0 |
| 7 | N/A | N/A | > 8 | >8 |
| 8 | N/A | ≤0.2 | > 8 | 1.7 |
| 9 | N/A | N/A | > 16 | >16 |
| 10 | N/A | ≤0.1 | > 8 | 1.2 |
| 11 | ≤0.3 | N/A | > 43.2 | >128 |
| 12 | N/A | N/A | > 128 | >128 |
N/A, selectivity index could not be calculated as the compound was inactive against the strain of interest or did not possess toxicity.