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Potent anthelmintic activity of tolfenpyrad (19) derivatives against H. contortus. The activity is shown for two in vitro assays: one for motility of xL3 (exsheathed L3 stage worms) and a second for development of xL3 into the L4 stage [169].
| ID | structure | IC50 (μM) in xL3 motility assay | IC50 (μM) in L4 development assay |
|
19 (tolfenpyrad) |
 |
2.9 | 0.03 |
| 20 |  |
2.03 | 0.0008 |
| 21 |  |
4.0 | 0.03 |
| 22 |  |
3.33 | 0.01 |
| 23 |  |
0.38 | 0.0007 |
| 24 |  |
0.7 | 0.0008 |
